منابع مشابه
Eukaryotic transcription initiation
Transcription is defined as the synthesis of RNA from a DNA template. In bacteria, transcription of all genes is catalysed by a single RNA polymerase, whereas in the eukaryotic nucleus, three different RNA polymerases — Pol I, Pol II and Pol III — carry out the synthesis of different classes of RNA. Pol I and Pol III transcribe a limited number of genes encoding ribosomal RNAs, transfer RNAs an...
متن کاملEukaryotic Initiation Complex Formation
Two distinct pathways have been elucidated which lead to the formation of an AUG-dependent initiation complex. One pathway involves the use of initiation factor Ml (IF-Ml) to promote AUG-dependent binding of the initiator tRNA to the 40 S subunit, followed by joining of the 60 S subunit in the presence of IF-MBA, IF-MBB, and GTP. The second pathway involves the IF-MP-directed binding of initiat...
متن کاملRegulation of the initiation of eukaryotic transcription.
DNA sequences that determine transcriptional regulation of a typical eukaryotic gene consist of a core promoter, which serves as a binding site for the GTF TFIID, and regulatory promoter or enhancer sequences, which bind transcriptional activators. The RNA polymerase II transcription machinery consists of over 50 proteins which are thought to bind to the core promoter in as few as two steps: bi...
متن کاملEukaryotic MCM proteins: beyond replication initiation.
The minichromosome maintenance (or MCM) protein family is composed of six related proteins that are conserved in all eukaryotes. They were first identified by genetic screens in yeast and subsequently analyzed in other experimental systems using molecular and biochemical methods. Early data led to the identification of MCMs as central players in the initiation of DNA replication. More recent st...
متن کاملPhosphorylation Stoichiometries of Human Eukaryotic Initiation Factors
Eukaryotic translation initiation factors are the principal molecular effectors regulating the process converting nucleic acid to functional protein. Commonly referred to as eIFs (eukaryotic initiation factors), this suite of proteins is comprised of at least 25 individual subunits that function in a coordinated, regulated, manner during mRNA translation. Multiple facets of eIF regulation have ...
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ژورنال
عنوان ژورنال: Nature
سال: 1992
ISSN: 0028-0836,1476-4687
DOI: 10.1038/357114a0